William C Zamboni Selected Research

9-aminocamptothecin

8/2008	Tumor, tissue, and plasma pharmacokinetic studies and antitumor response studies of docetaxel in combination with 9-nitrocamptothecin in mice bearing SKOV-3 human ovarian xenografts.
5/2006	Clinical and pharmacokinetic study evaluating the effect of food on the disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in patients with solid tumors.
7/2005	Relationship between plasma exposure of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite and antitumor response in mice bearing human colon carcinoma xenografts.

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William C Zamboni Research Topics

Disease

72	Neoplasms (Cancer) 01/2021 - 09/2002
8	Breast Neoplasms (Breast Cancer) 10/2019 - 03/2012
8	Ovarian Neoplasms (Ovarian Cancer) 01/2019 - 02/2008
7	Melanoma (Melanoma, Malignant) 10/2017 - 09/2002
6	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018 - 08/2004
5	Carcinoma (Carcinomatosis) 07/2013 - 07/2005
4	Glioma (Gliomas) 01/2020 - 07/2008
4	Ovarian Epithelial Carcinoma 03/2016 - 10/2008
3	Glioblastoma (Glioblastoma Multiforme) 04/2020 - 10/2018
2	Triple Negative Breast Neoplasms 01/2021 - 11/2017
2	Diarrhea 01/2018 - 01/2004
2	Colorectal Neoplasms (Colorectal Cancer) 07/2005 - 01/2004
1	Neoplasm Metastasis (Metastasis) 04/2020
1	Brain Neoplasms (Brain Tumor) 01/2020
1	Endometrial Neoplasms (Endometrial Cancer) 01/2019
1	Obesity 01/2019
1	Wounds and Injuries (Trauma) 01/2017
1	Fallopian Tube Neoplasms 09/2015
1	Body Weight (Weight, Body) 01/2015
1	Inflammation (Inflammations) 04/2014
1	Hypersensitivity (Allergy) 04/2014

Drug/Important Bio-Agent (IBA)

22	Pharmaceutical PreparationsIBA 01/2021 - 02/2003
15	Docetaxel (Taxotere)FDA Link 01/2021 - 04/2005
11	1-dodecylpyridoxal (PLD)IBA 10/2019 - 01/2012
9	liposomal doxorubicin (Doxil)FDA Link 01/2021 - 01/2013
7	Cisplatin (Platino)FDA LinkGeneric 01/2019 - 09/2002
6	Irinotecan (Camptosar)FDA LinkGeneric 02/2016 - 01/2004
6	Carboplatin (JM8)FDA LinkGeneric 03/2012 - 01/2005
6	belotecanIBA 02/2012 - 12/2007
5	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2012
5	PlatinumIBA 01/2017 - 09/2002
5	rubitecanIBA 08/2008 - 08/2004
4	ChemokinesIBA 01/2020 - 10/2015
4	Cytotoxins (Cytolysins)IBA 01/2019 - 08/2005
4	CamptothecinIBA 05/2012 - 08/2004
3	ClaudinsIBA 01/2021 - 10/2012
3	Paclitaxel (Taxol)FDA LinkGeneric 04/2020 - 02/2008
3	Immunoconjugates (Immunoconjugate)IBA 01/2019 - 08/2017
3	Biological ProductsIBA 01/2019 - 01/2015
3	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2019 - 09/2015
3	Capecitabine (Xeloda)FDA Link 01/2018 - 04/2005
3	taxaneIBA 11/2017 - 09/2006
3	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2017 - 01/2013
3	Liposomes (Liposome)IBA 01/2013 - 04/2004
3	9-aminocamptothecinIBA 08/2008 - 07/2005
3	Topotecan (Hycamtin)FDA LinkGeneric 08/2005 - 02/2003
2	c-Mer Tyrosine KinaseIBA 01/2020 - 10/2018
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2020 - 10/2018
2	LigandsIBA 01/2020 - 12/2014
2	gamma-glutamylaminomethylsulfonic acid (GAMS)IBA 01/2020 - 10/2018
2	Hormones (Hormone)IBA 01/2019 - 01/2016
2	folfirinoxIBA 01/2018 - 02/2016
2	Phenobarbital (Luminal)FDA Link 01/2018 - 10/2012
2	DNA (Deoxyribonucleic Acid)IBA 02/2016 - 03/2012
2	Antineoplastic Agents (Antineoplastics)IBA 02/2016 - 12/2007
2	Lapatinib (GW572016)FDA Link 10/2012 - 10/2008
2	liposomal SPI-77IBA 10/2011 - 04/2004
2	Glycerol (Glycerine)FDA LinkGeneric 09/2008 - 07/2008
2	lysine diisocyanate-glycerol poly(urea-urethane)IBA 09/2008 - 07/2008
2	7- tert- butyldimethylsilyl- 10- hydroxycamptothecinIBA 09/2008 - 07/2008
2	DNA AdductsIBA 04/2004 - 09/2002
1	CollagenIBA 01/2021
1	AcidsIBA 04/2020
1	CytokinesIBA 01/2020
1	Interleukin-8 (Interleukin 8)IBA 01/2020
1	MRX-2843IBA 01/2020
1	Drug CarriersIBA 10/2019
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 10/2019
1	Monoclonal AntibodiesIBA 01/2019
1	UNC2025IBA 10/2018
1	Glial Fibrillary Acidic ProteinIBA 10/2018
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2018
1	SolutionsIBA 01/2018
1	NVP-BKM120IBA 01/2018
1	Alanine Transaminase (SGPT)IBA 01/2018
1	trans-sodium crocetinate (crocetin)IBA 03/2016
1	Technetium Tc 99m Sulfur Colloid FDA Link 03/2016
1	Leucovorin (Folinic Acid)FDA Link 02/2016
1	Fluorouracil (Carac)FDA LinkGeneric 02/2016
1	HydrogelsIBA 01/2016
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2016
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 10/2015
1	Gemcitabine FDA Link 02/2015
1	Vascular Endothelial Growth Factor CIBA 12/2014
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2014
1	CC ChemokinesIBA 12/2014
1	Ether (Diethyl Ether)IBA 03/2014
1	ProdrugsIBA 03/2014
1	BromineIBA 01/2014
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2013
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2012
1	AZD 6244IBA 10/2012
1	dactolisibIBA 10/2012
1	MitogensIBA 10/2012

Therapy/Procedure

16	Therapeutics 04/2020 - 01/2004
11	Drug Therapy (Chemotherapy) 01/2021 - 09/2002
1	Radiotherapy 01/2021
1	Combination Drug Therapy (Combination Chemotherapy) 02/2016
1	Precision Medicine 01/2016
1	Immunomodulation 04/2014